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Achieve precise and reliable results in your other peptides using a MOTS-C protocol..
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino-acid peptide encoded directly within mitochondrial DNA rather than the cell nucleus. [1]
Core Characteristics
Definition: A signaling peptide (mitokine) derived from the 12S rRNA region of the mitochondrial genome with the sequence MRWQEMGYIFYPRKLR.
Discovery: Identified around 2015 by researchers at the University of Southern California (USC).
Age-Related Decline: Natural levels of MOTS-c decrease as the body ages.
Mechanism of Action
Stress Translocation: At rest, it resides in the mitochondria, but under metabolic or exercise stress, it moves into the cell nucleus.
AMPK Activation: It activates the AMPK pathway, which mimics the cellular effects of exercise, increases intracellular NAD+, and regulates nuclear gene expression.
Antioxidant Response: It triggers antioxidant response elements (AREs) to lower oxidative stress and inflammation.
Therapeutic Potential & Research Status
Metabolic Health: Preclinical studies show it improves insulin sensitivity, supports glucose metabolism in skeletal muscle, and helps protect against diet-induced obesity.
Regulatory Status: MOTS-c is not FDA-approved, lacks large-scale human clinical trials, and is restricted or banned in certain athletic/sporting events. Most current evidence stems from animal models and early-phase research.
Unleash the full potential of your research projects with our precision-engineered research materials, designed for those who demand the highest standards in their scientific endeavors
High purity 3rd party tested lyophilized powder for consistent research results.
Secure, airtight vials ensure maximum freshness and stability.
Clearly labeled for easy identification .
Achieve precise and reliable results in your other peptides using a MOTS-C protocol..
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino-acid peptide encoded directly within mitochondrial DNA rather than the cell nucleus. [1]
Core Characteristics
Definition: A signaling peptide (mitokine) derived from the 12S rRNA region of the mitochondrial genome with the sequence MRWQEMGYIFYPRKLR.
Discovery: Identified around 2015 by researchers at the University of Southern California (USC).
Age-Related Decline: Natural levels of MOTS-c decrease as the body ages.
Mechanism of Action
Stress Translocation: At rest, it resides in the mitochondria, but under metabolic or exercise stress, it moves into the cell nucleus.
AMPK Activation: It activates the AMPK pathway, which mimics the cellular effects of exercise, increases intracellular NAD+, and regulates nuclear gene expression.
Antioxidant Response: It triggers antioxidant response elements (AREs) to lower oxidative stress and inflammation.
Therapeutic Potential & Research Status
Metabolic Health: Preclinical studies show it improves insulin sensitivity, supports glucose metabolism in skeletal muscle, and helps protect against diet-induced obesity.
Regulatory Status: MOTS-c is not FDA-approved, lacks large-scale human clinical trials, and is restricted or banned in certain athletic/sporting events. Most current evidence stems from animal models and early-phase research.
Unleash the full potential of your research projects with our precision-engineered research materials, designed for those who demand the highest standards in their scientific endeavors
High purity 3rd party tested lyophilized powder for consistent research results.
Secure, airtight vials ensure maximum freshness and stability.
Clearly labeled for easy identification .